File Name: autophagy in human health and disease .zip
Molecular mechanisms protecting against tissue injury View all 9 Articles. Autophagy was originally described as a highly conserved system for the degradation of cytosol through a lysosome-dependent pathway. In response to starvation, autophagy degrades organelles and proteins to provide metabolites and energy for its pro-survival effects.
Researchers have linked autophagy to several positive health effects. They also believe that a person might be able to induce autophagy by fasting.
Autophagy is an essential mechanism to sustain homeostasis at cellular and organismal levels. Concerning human health, an increasing number of examples underline its value as a novel therapeutic target since autophagy modulation may potentially become an effective new strategy to combat cancer, neurodegeneration, and infection. Beneficially, autophagy modulation may also slow down age-related tissue decline. A relationship between redox disorder and autophagy signaling has already been described but is still not well characterized. Oxidative stress can arise in cells because of different reasons; among them are metal imbalance and perturbation or perforation of cellular membranes by various insults. In addition, it has been recently hypothesized that amyloid prefibrillar oligomers and proteostasis constitute a metabolic balance between synthesis and degradation of proteins, with protein misfolding and accumulation of the aggregated proteins shifting the balance. All these processes are in a direct or indirect way relying on good performance of autophagy to clear the cells of unnecessary burdens and thus rejuvenate them.
Four forms of autophagy have been identified: macroautophagy , microautophagy , chaperone-mediated autophagy CMA , and crinophagy. In crinophagy the least well-known and researched form of autophagy , unecessary secretory granules are degraded and recycled. In disease, autophagy has been seen as an adaptive response to stress, promoting survival of the cell; but in other cases it appears to promote cell death and morbidity. In the extreme case of starvation, the breakdown of cellular components promotes cellular survival by maintaining cellular energy levels. The word "autophagy" was in existence and frequently used from the middle of the 19th century. Autophagy was first observed by Keith R. Porter and his student Thomas Ashford at the Rockefeller Institute.
Autophagy is the natural cellular process of construction and destruction mechanisms involved in physiological development and pathological genesis. From embryogenesis to post-natal development, autophagy or autophagocytosis plays a critical role in tissue and organ architecture along with the differentiation of normal tissue and remodelling of pathological advancement. Aiming to expand the therapeutic potential of autophagy, many researchers focus on developing new drugs or treatment strategies for Parkinson's disease, rheumatic diseases and oncogenesis by controlling cell fate via regulating molecular pathways. This series aims to highlight essential molecular and cellular mechanisms for understanding autophagy and its comprehensive associations with cardiac vascular diseases, carcinogenesis, liver diseases, neuronal degeneration and other related disorders. Original research papers and review articles will be considered for publication in this series.
It seems that you're in Germany. We have a dedicated site for Germany. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students. Kursad Turksen received his Ph.
If the address matches an existing account you will receive an email with instructions to reset your password. If the address matches an existing account you will receive an email with instructions to retrieve your username. Address correspondence to: Prof. Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer.
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This work was supported by the National. Institutes of Health Public Health Service grant GM (to D.J.K.). Review. Autophagy and Human Disease. AbstrAct.
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Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implications Andrew Thorburn 5.Awterreenea 11.05.2021 at 01:49
Autophagy in Human Health and Disease. Augustine M.K. Choi, M.D., Stefan W. Ryter, Ph.D., and Beth Levine, M.D.. From the Department of.Pirecastemp 11.05.2021 at 15:15
Request PDF | On May 9, , Andrea Doria and others published Autophagy in Human Health and Disease | Find, read and cite all the.