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Pdf Assessment And Manifestation Of Central Sensitisation Across Different Chronic Pain Conditions

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Introduction: The presence of a temporomandibular disorder is one of the most frequent causes of orofacial pain OFP. When pain continues beyond tissue healing time, it becomes chronic and may be caused, among other factors, by the sensitization of higher-order neurons. The aim of this study is to describe psychological characteristics of patients with chronic OFP, their peripheral pain threshold, and electroencephalography EEG recording, looking for possible signs of central sensitization CS.

Assessment and manifestation of central sensitisation across different chronic pain conditions

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Treatments for neuropathic pain

Different neuroplastic processes can occur along the nociceptive pathways and may be important in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain sensitisation or loss desensitisation of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features. The fundamental understanding and quantitative assessment of particularly some of the central sensitisation mechanisms can be translated from preclinical studies into the clinic. The clinical perspectives are implementation of such novel information into diagnostics, mechanistic phenotyping, prevention, personalised treatment, and drug development. The aims of this paper are to introduce and discuss 1 some common fundamental central pain mechanisms, 2 how they may translate into the clinical signs and symptoms across different chronic pain conditions, 3 how to evaluate gain and loss of function using quantitative pain assessment tools, and 4 the implications for optimising prevention and management of pain.

Hyperexcitability of the central nervous system plays an important role in the development and maintenance of chronic pain in adults. This knowledge has led to improved treatment strategies within this population. In children, however, research on the presence of central hyperexcitability is scarce. To further investigate this topic in children with chronic pain, there is a need for a clear literature overview. The literature search was performed using the electronic databases PubMed and Web of Science.


Request PDF | Assessment and manifestation of central sensitisation across different chronic pain conditions | Significance: Central sensitisation is an important.


Assessment and manifestation of central sensitisation across different chronic pain conditions

Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain is sometimes determined by the amount of time since onset. Two commonly used markers are pain that continues at 3 months and 6 months since onset, [1] but some theorists and researchers have placed the transition from acute to chronic pain at 12 months. Chronic pain may originate in the body, or in the brain or spinal cord. It is often difficult to treat.

The identification of central sensitization CS is an important aspect in the management of patients with chronic musculoskeletal pain. Several methods have been developed, including clinical indicators and psychophysical measures. However, whether clinical indicators coincide with the psychophysical test of CS-related sign and symptoms is still unknown.

Chronic pain

Previous reviews have reported that manifestations of pain sensitization may play an important role in the pain experienced by people with knee osteoarthritis. However, it is unknown if manifestations of pain sensitization are common features across other painful knee disorders or if sensitization requires targeted intervention. This review aims to synthesize the published research investigating manifestations of pain sensitization in painful knee disorders and to evaluate if the manifestations of pain sensitization change in response to treatment. We searched Medline, Embase, CINAHL, Web of Science, Sportsdiscus, and Cochrane Central for studies that investigated between-group differences knee pain vs pain-free subjects or the effect of treatment on manifestations of pain sensitization. Two reviewers independently assessed studies for inclusion and quality.

Metrics details. The identification of central sensitization CS is an important aspect in the management of patients with chronic musculoskeletal pain. Several methods have been developed, including clinical indicators and psychophysical measures. However, whether clinical indicators coincide with the psychophysical test of CS-related sign and symptoms is still unknown. Therefore, the present study aimed to analyze the diagnostic accuracy of the clinical indicators in identifying CS-related sign and symptoms in patients with musculoskeletal pain.


Central sensitisation is an important manifestation involved in many different chronic pain conditions. Central sensitisation can be different to assess and.


Central NP is the result of a central lesion or disease such as stroke, multiple sclerosis or spinal cord injury [2] , whereas peripheral NP occurs from dysfunction or damage to peripheral nerves [3]. A study in Canada reported that A study in the United States US revealed that the prevalence rates for NP determined by either clinical examination or self-reporting were 9. It is difficult to obtain a true estimate, due to epidemiological studies using different methods of assessment and different definitions of NP [8]. A recent systematic review of epidemiological NP studies across the world by van Hecke et al.

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4 Comments

Clarrotempwealth1992 21.05.2021 at 17:04

Central sensitisation is an important manifestation involved in many different chronic pain conditions. Central sensitisation can be different to.

Elbio V. 27.05.2021 at 00:06

central sensitisation) across different chronic pain conditions, (3) how to evaluate gain and loss of function using quantitative pain assessment.

Glycinalun 27.05.2021 at 14:11

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Arnaud L. 29.05.2021 at 18:21

The role of central sensitization in refractory pain-related diseases has not yet been clarified.

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