File Name: microbial genetics and molecular biology textbook .zip
This module is designed to consolidate and expand knowledge of microbial genetics and virology obtained in year 2. Students should gain an understanding of how bacterial genetic material can be altered, by mutation, horizontal gene transfer and programmed gene rearrangements. Emphasis will be placed on the nature of the molecular mechanisms involved in these processes. The diversity of DNA repair mechanisms and the importance of transposable elements and suppressor mutations as tools for the molecular microbiologist will be explored. Levels of transcriptional and translational control and the role of quorum sensing in bacterial communities will be introduced. Students will consider the role of bacteriophage in the environment, involvement in bacterial pathogenicity and the potential use of phage in the treatment of infectious disease.
The field of molecular biology studies macromolecules and the macromolecular mechanisms found in living things, such as the molecular nature of the gene and its mechanisms of gene replication, mutation, and expression. Despite its prominence in the contemporary life sciences, molecular biology is a relatively young discipline, originating in the s and s, and becoming institutionalized in the s and s. It should not be surprising, then, that many of the philosophical issues in molecular biology are closely intertwined with this recent history. The rich historiography of molecular biology can only be briefly utilized in this shortened history see, for example, Abir-Am , , , ; Burian a; Canguillhem ; de Chadarevian , ; de Chadarevian and Gaudilliere ; de Chadarevian and Strasser ; Deichmann ; Fisher ; Hausmann ; Holmes ; Judson , ; Kay ; Marcum ; Morange a, ; Olby , , , ; Powell et al. Also see autobiographical accounts by biologists, such as Brenner ; Cohen ; Crick ; Echols ; Jacob ; Kornberg ; Luria ; Watson , , ; Wilkins
William Astbury described molecular biology in in Nature , as:. It is concerned particularly with the forms of biological molecules and [ It must at the same time inquire into genesis and function. Some clinical research and medical therapies arising from molecular biology are covered under gene therapy whereas the use of molecular biology or molecular cell biology in medicine is now referred to as molecular medicine. Molecular biology also plays important role in understanding formations, actions, and regulations of various parts of cells which can be used to efficiently target new drugs , diagnose disease, and understand the physiology of the cell.
Between and , a new phenomenon emerged in the field of bacteriology. And yet, to describe bacteria as sexually reproducing organisms, the definition of sex itself had to change. Despite manifold contradictions and the availability of alternative language, the notion of sexually active even promiscuous single-celled organisms has persisted, even into contemporary textbooks on cell biology and genetics. This is a preview of subscription content, access via your institution. Rent this article via DeepDyve. Adelberg, Edward A.
NCBI Bookshelf. Molecular Biology of the Cell. New York: Garland Science; Ultimately, one wishes to determine how genes—and the proteins they encode—function in the intact organism.
Bacteriophages viruses that infect bacteria are fascinating organisms that have played and continue to play a key role in bacterial genetics and molecular biology. Phage can confer key phenotypes on their host, for example converting a non-pathogenic strain into a pathogen, and they play a key role in regulating bacterial populations in all sorts of environments.