File Name: standardization and storage of bcg vaccine .zip
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Tuberculosis - Expanding Knowledge.
Copy embed code:. Automatically changes to Flash or non-Flash embed. WordPress Embed Customize Embed. URL: Copy. Presentation Description BCG vaccine. Madhav Thakur Dr. Sheetu Jailkhani M. Results of vaccination. Duration of immunity. First human vaccinated by intradermal technique- Mass BCG vaccination campaign in Strain used- M. Organism was subcultured every 3 weeks for 13 years for cycles.
PowerPoint Presentation: Two types of strains- 1. Quality control is ensured by the international reference centre at Copenhagen. Danish strain is being used since Included in EPI vaccination schedule- AIM: AIM T o induce a benign artificial primary infection with attenuated tubercle bacilli, and thus reduce the morbidity and mortality from primary tuberculosis among those most at risk.
WHO recommends - Danish bovine strain. Two types of vaccines- Liquid Fresh vaccine. Reconstituent - Normal Saline. Distilled water is hypotonic and may cause rupture of bacterial cells- so not used - Reconstituted vaccine must be used within 3 hrs. Study should be carried out in children on at least one batch of vaccine per year. Extent of local reaction to BCG vaccination is proportional to Total bacterial mass.
PowerPoint Presentation: Level of Tuberculin sensitivity induced is related to number of viable particles. Test for number of viable bacilli- 1 Colony growth in media. Other tests- Test of - Identity - contamination - Safety. Repeat vaccine can be given if absence of scar or lack of tuberculin sensitivity. Up to 1 month Other route- Percutaneous with multipuncture device.
Most common site- Deltoid region of left arm. Other sites- Thigh, Forearm Tuberculin syringe 26 gauge Omega microstat syringe, 0. Oral vaccination required larger doses of BCG e.
Difficult to control the effective dose with oral administration. Intradermal injection is more efficient at inducing tuberculin conversion Cervical lymphadenopathy attributed to oral administration. Introduced in SITE is the lower deltoid area - to involve the axillary instead of the upper clavicular lymph nodes-to minimize complications from post-vaccination lymphadenopathy. Phenomena after vaccination : Phenomena after vaccination Intradermal BCG injection 5 mm wheal Immediately wks Papule 5 wks mm Papule Shallow Ulcer covered with crust 6- 12 wks Healing with permanent tiny round scar mm wks Mantoux test positive What is direct BCG vaccination?
Vaccination without a prior Tuberculin test. Reduces cost. No adverse effects even if BCG is given to Tuberculin positive reactors. Benefits of vaccination:: Benefits of vaccination: Protection against most serious forms of disease like Meningitis and disseminated disease. BCG vaccination prevents massive lympho-haematogenous dissemination. Protective efficacy of BCG against various clinical forms of tuberculosis.
Myint et al. Protection - years of vaccination. Ipsilateral side Musculoskelatal lesions Osteomyelitis Multiple lymphadenitis Non fatal disseminated lesions Fatal disseminated lesions Immuno -suppressed Individuals. Hypogammaglobulinemia Generalized eczema Infective dermatosis.
It would be unusual for TB bacilli to become airborne from ulcerated site. When to shift from routine universal BCG vaccination to selective vaccination of high risk group? Efficient notification system Low endemicity criteria- 1. Average annual notification rate of smear positive pulmonary TB cases below 5 per 1 lakh. Average annual risk of Tb infection below 0. Needs special route intradermal , special syringe and needle and special dose 0.
H 37 Ra-mutant strain of M. Chapter 12, BCG. James Nuttal. Paediatric infectious disease unit. Red cross childrens hospital, University of cape town Indian Journal for the Practicing Doctor. Rehana Kausar , MD Vol. Safe vaccine handling, cold chain and Immunizations. A manual for the newly independent states. Global programme for vaccines and immunization. Expanded programme on immunization. World health organization, Geneva, The immunological basis for immunization series.
Module 5:tuberculosis. Global programe for vaccines and immunization. Expanded programe on immunization. Dr Julie Milstien. Scientist, Biologicals Unit. Geneva Follow us on:.
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Presentation Transcript. PowerPoint Presentation: Lubeck disaster: 72 children die from oral BCG preparation contaminated with virulent strain- Multiple puncture technique Scarification technique Included in EPI vaccination schedule- AIM: AIM T o induce a benign artificial primary infection with attenuated tubercle bacilli, and thus reduce the morbidity and mortality from primary tuberculosis among those most at risk. Freeze dried vaccine Stable. PowerPoint Presentation: Storage - away from direct light.
Why Intradermal route is favoured? Phenomena after vaccination : Phenomena after vaccination Intradermal BCG injection 5 mm wheal Immediately wks Papule 5 wks mm Papule Shallow Ulcer covered with crust 6- 12 wks Healing with permanent tiny round scar mm wks Mantoux test positive.
A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylactic to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen , or therapeutic to fight a disease that has already occurred, such as cancer. The administration of vaccines is called vaccination. Vaccination is the most effective method of preventing infectious diseases;  widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio , measles , and tetanus from much of the world. The effectiveness of vaccination has been widely studied and verified;  for example, vaccines that have proven effective include the influenza vaccine ,  the HPV vaccine ,  and the chicken pox vaccine.
In evaluating BCG vaccination, one must first define its potentialities. BCG vaccine, properly administered, will increase the resistance of both animal and man to virulent tubercle bacilli. This resistance is not absolute.
Rates of protection against tuberculosis infection vary widely and protection lasts up to twenty years. Serious side effects are rare.
If you create an account, you can set up a personal learning profile on the site. BCG vaccine is a freeze-dried powder, supplied in small glass bottles called ampoules. Vaccines that come as powders must be mixed with a liquid called a diluent. This process is known as reconstitution , which means thoroughly mixing the powder with the diluent to activate the vaccine before it can be administered. Before use, you must reconstitute BCG vaccine powder with the appropriate diluent supplied for this purpose, using a mixing syringe to mix the diluent with the powder in the ampoule. You will learn how to do this in Study Session 4. The vaccine powder may be frozen for long-term storage, but the diluent and the reconstituted vaccine must never be frozen.
To enhance the TS of the vaccine, some prevalent stabilizers in different concentrations were added to the final formulation of BCG bulk prior to Freeze-drying process. We found a formulation more effective than the current stabilizer for retaining the higher viability of lyophilized BCG vaccine produced by Pasteur Institute of Iran.
Even though the BCG vaccine is still widely used, results on its effectiveness in preventing mycobacterial diseases are partially contradictory, especially regarding Buruli Ulcer Disease BUD. The present study was performed in three different countries and sites where BUD is endemic: in the Democratic Republic of the Congo, Ghana, and Togo from through The large study population was comprised of cases with laboratory confirmed BUD and controls, mostly family members or neighbors.
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Я занесу им, а вы, когда увидите мистера Густафсона, скажете ему, где его паспорт. - Подождите! - закричал Ролдан. - Не надо впутывать сюда полицию.
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